Surface functionnalization

Surface functionnalization and applications


The applications of surface functionalization are multiple and cover large fields at the interface between chemistry and biology. The aim of this course is to focus on two challenging applications: surface functionalization for biosensors and for (electro)catalysis. The course is structured into two modules differentiated by the nature of the functionalized material which (mineral/inorganic or biological).


I. Short introduction on biomolecules (DNA, proteins, enzymes, sugars…)

II. Functionalization of mineral and inorganic based-materials and related characterization techniques (fluorescence microscopy, AFM, SEM, ellipsometry…)

  DNA, sugars and proteins
  • Physisorption, chemisorption
  • Self-assembly on conducting and semi-conducting surfaces (silanization, thiol self assembly)
  • Electrofunctionnalization: conducting polymers, diazonium salts
  • Auto-organization of biomolecules : origami, DNA wires, protein auto-assembly, protein organized around organizing structure (Metals…)
  •  Applications: biosensors, stimulating electrodes and anti-fouling surfaces
  • Functionnalization
  • Applications: (photo)electrocatalytic water splitting (reduction of protons, water oxidation), CO2 reduction
  • Functionnalization
  • Applications: hydrogenases, CO2 reductase …

III. Functionnalization of bio-based nanomaterials

  •  Functionnalization with catalysts
  •  Applications
  •  Functionnalization (bioconjugation) with catalysts (artificial enzymes) and nanoparticles
  •  Applications
Published on February 22, 2021
Updated on February 22, 2021