Spatiotemporal-controlled chemotherapy release

by light- and radiotherapy-responsive liposomes
Liposomes have been the most successful type of nanomedicine for cancer patients, playing a leading role in improving the tolerability of chemotherapeutics.
However, to advance the success of liposomal drug delivery and cancer treatment, new approaches to physically trigger drug release in cancer tissues and increase the permeability of the protective cancer stroma are needed. This project will investigate whether photocatalytic and radiocatalytic nanomaterials can be integrated in a drug delivery modality to alleviate cancer desmoplasia and improve the efficacy of the encapsulated drugs.
We are looking for a motivated student with affinity for cross-disciplinary research, involving biology, biophysics, and biochemistry. For the M1 interview, a literature study will be performed, of which the topic is flexible and depends upon the expertise of the candidate. The master internship will involve nanoliposome synthesis and characterization, and to study their therapeutic effects on cancer organoids. The goal for the candidate is to graduate with at least one first-author publication.

For more information:

Broekgaarden et al., Biomaterials 2019
Bulin et al., Adv. Science 2020
Obaid et al., Nano Lett 2019
Published on July 27, 2021
Updated on September 9, 2022