Biomedical ultrasound imaging is one the most widespread diagnostic modality. Many applications, such as obstetric imaging, are based on endogenous tissue contrast. However, ultrasound imaging may also benefit from contrast agents, which aim at enhancing contrast and/or specificity. Ultrasound contrast agents consist of encapsulated air bubble, with possibly very large scattering cross-sections with respect to their size. Not only can ultrasound contrast agents be used to enhanced ultrasound contrast [1], but they can also be functionalized to carry and deliver drugs, and enable super-resolution imaging [2]. Although ultrasound contrast agents have been used for decades [1], simultaneous imaging and manipulating contrast agents remains a key challenge for in vivo biomedical applications, where the contrast agents are carried by blood flow.
In this project, the main objective is to develop a proof-of-concept experiment in which air bubbles in a water tank are simultaneously localized and manipulated by use of an ultrasound array driven by a state-of-the-art ultrasound electronics.
The project can be carried out as part of a research intensive track, as M1 or M2 internships, or as part of Graduate Schools requirements. Students with a physics or mechanics/acoustics background are welcome to apply. Python and/or Matlab programming skills and a basic knowledge on wave propagation principles are required.
Expected skills
The project is adapted to master students following the tracks : M1 Soft Matter and Biophysics - M1 Applied Mechanics - Phelma Biomedical Engineering.
It can be carried out as part of a research intensive track, as M1 or M2 internships, or as part of Graduate Schools requirements. Students with a physics or mechanics/acoustics background are welcome to apply. Python and/or Matlab programming skills and a basic knowledge on wave propagation principles are required.
Bibliography:
[1] Frinking, P., Segers, T., Luan, Y., & Tranquart, F. (2020). Three decades of ultrasound contrast agents: a review of the past, present and future improvements. Ultrasound in medicine & biology, 46(4), 892-908.
[2] Errico, C., Pierre, J., Pezet, S., Desailly, Y., Lenkei, Z., Couture, O., & Tanter, M. (2015). Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Nature, 527(7579), 499-502.
