Inter-regulation of colonic motility, hydrodynamics and bacterial metabolitesgical Systems

a collaboration with the Elaidy Lab in Amsterdam
The gastrointestinal tract, particularly the colon, harbors a diverse microbiota community whose implications for human health are just beginning to be understood. The gut microbiota aids in digesting indigestible particles. This process results in the secretion of metabolites in the colon, which are absorbed by the bloodstream and play a crucial role in regulating colonic motility and mass transfer phenomena within the colon.
Our multidisciplinary research team is dedicated to deciphering the intricate inter-regulation pathways between colonic motility, hydrodynamics, and bacterial metabolites. Based in four labs across Grenoble (LRP and TIMC), Amsterdam (Elaidy Lab), and Paris (Lab. Jean Perrin), we cover different scientific area: complex rheology in biological systems, smooth muscle physiology, microbiology and biophysical modelling of transport phenomena.
In your first year (M1), you will be based in Grenoble, where you will develop experimental methods to study colon motility and hydrodynamics in ex-vivo models, exploring their relation with the rheology of digesta. This hands-on experience will provide you with invaluable insights into experimental techniques and research methodologies.
In your second year (M2), you will have the opportunity to join the Elaidy Lab in Amsterdam, where you will leverage the methods and knowledge gained during your M1 internship to investigate the intricate inter-regulation pathways influenced by bacterial metabolites.
The experimental techniques to be used encompass micro- / milli-fluidics, image analysis, rheometry, and other cutting-edge methodologies. Collaborating closely with researchers and PhD fellows, you will delve deeper into the fascinating world of gut microbiota and its implications for human health.

Expected skills
This internship is devoted to a student of the program Soft Nanosciences followint the master M1 Soft Matter and Biophysics - or the M1 Applied Mechanics.
A first (optional) course in Active Matter is a plus.
French students of the Grad School can be supported by a grant of outgoing mobility for their intership in Amsterdam.
Published on April 9, 2024
Updated on April 9, 2024