M2 Nano-medecine

Resp. : Prof. Didier Delabouglise

This track leaded by Grenoble-INP, is devoted to the new technologies in medical imaging involving nano- or molecular markers, as well as the therapeutic use of nano-particules. Taught courses include general biology courses mainly directed at students joining the program in the second year. It also includes a number of courses dealing with the various methods of medical imaging from acoustics to magnetic resonance and X-rays, image processing issues, nano- and molecular markers, and courses in structural biology.  These courses are also avalable to students in the Physics or Chemistry majors.

See here for the 1st year program of Nano-medecine.

In addition to these courses, a long research internship in a laboratory is compulsory to complete the program.

Fall semester: 30 ECTS courses from september to january

Common program in nanosciences: 6 ECTS
                       Micro- Nanofabrication  (3 ECTS)
                       Research Training (3 ETCS)

Core courses in Nano-Medecine: 9 ECTS
                       Image processing and molecular markers ( 6 ECTS)
                       Magnetic Resonance Imaging (3 ECTS)

Broadening courses: 15 ECTS to be chosen in the list below or the general list of broadening courses
                       Medical Image Processing (3 ECTS)
                       Optical Spectroscopy (3 ECTS)
                       Structural and Dynamical Biology (6 ECTS)
                       Statistical Analysis and Simulations (6 ECTS)
                       Physiology and Neurosciences (6 ECTS)
                       Any other course of the Nano-bioscience track

Spring semester: 30 ECTS from february to june

General interest courses: 6 ETCS
            Foreign language (french for non-french speaking students):  3 ECTS
              3 ECTS among
                       Intellectual Property and Valorization  (3 ECTS)
                       Capita Selecta Lectures Series in Nanosciences (3 ECTS)
                       Other courses offered by the Service of Transverse Teachings (SET)

Master thesis: 24 ECTS.
Research project performed during a research internship of 5 months minimum.

 

Image Processing and Molecular Markers - 6 ECTS
Contact:

Goal: The course gives an introduction to the basis techniques of image processing.
It is completed by a serie of seminars on the development and use of contrast agents and molecular markers in biomedical imaging and therapy
Content:

  • Digital images and representations
  • Image quality improvment
  • Image restauration and filtering
  • Contours extraction
  • Image segmentation
  • Visual perception
  • Colour images
  • 3 lab sessions: 2x3h to illustrate some basic image processing methods + 1x3h to study an iris recognition algorithm

Seminars are devoted to topics suchs as contrast agents and molecular markers for ultrasound, X-Ray and MRI imaging ; the development and use of visible and infrared fluorophores ; and applications to cardiovascular diseases, cancer and neurodegenerative diseases.

Prerequisites: Basic notions of signal processing. Basic notions of Matlab programming
Bibliography: Handbook of image and video processing, Al Bovik, 2000, Academic press
Images numériques couleur : de l'acquisition au traitement, A. Tremeau, C. Fernandez-Maloigne, P. Bonton, 2004, Dunod
Introduction au traitement d'images, Gilles Burel, 2001, Hermès
Traitement et analyse des images numériques, S. Bres, J.M. Jolion, F. Lebourgeois, 2003, Hermès

Magnetic Resonance Imaging - 3 ECTS
Contact:   See also here

Goal: The course will provide a thorough understanding of the MRI techniques.
Content:

  • Space coding
  • selective impulsions
  • reciprocal space;
  • the different imaging techniques
  • image contrast
  • image artifacts
  • applications
  • instrumentation

keywords : NMR, electromagnetism, radio-frequency, resonant circuits, quantum mechanics, the Zeeman effect, spin operators

Prerequisites : Basic principles of NMR. A good knowledge of maths and physics
Bibliography: Principles of Nuclear Magnetism (Oxford Science Publications), A. Abragam;
Pulse and Fourier Transform NMR (Academic Press), T.C. Farrar, E.D. Becker;
Mécanique quantique (Hermann), C. Cohen-Tannoudji ;
Electromagnétisme(InterEditions), Feynman;
MagnétismeII: matériaux et applications (PUG), E. Trémolet de Lacheisserie;
Circuits électroniques et amplificateurs (Dunod), L. Chambeau.

Medical Image Processing - 3 ECTS
Contact: . See also here

Goal: Introduction to medical Imaging
Content:
     Introduction
     X-Ray computed tomography
     Image segmentation
     Binary image quantification
     3D imaging
     the DICOM standard
        Labworks: LW1 - Radon transform and image reconstruction techniques
        LW2 - Image segmentation : threshold and snakes
        LW3 - Image quantitative analysis

Prerequisite: Image Processing
Bibliography: A. Kak, M. Slaney principles of computerized tomographic imaging, IEEE press, 1998
A. Jain Fundamentals of digital image processing, Prentice Hall, 1989
H. Fanet Imagerie médicale à base de photons, Editions Lavoisier 2010
Sethien et al. Level set methods and fast matching methods, Cambridge university press 1999

Optical Spectroscopy - 3 ECTS

Contact:

Goal: Optical spectroscopy concerns itself with the interaction between light and matter. In this lecture we present a theoretical framework to discuss the absorption, emission, and luminescence properties of atomic and molecular systems. Experimental techniques will be discussed, including modern and state-of-the-art techniques used in the environmental (e.g., infrared trace gas detection) and life sciences (such as Raman non-linear spectroscopies).

Physiology and Neurosciences (6 ECTS)
Contact:       See also here

Goal: This course covers basics concepts in physiology from cardiac, respiratory and renal physiology to the knwoledge of some human pathologies. It introduces main conceps in neurosciences, from neuron to simple neural fonctions, and some neurodegenerative diseases. The course provides contacts with physicians and medical research.

Content :      Lectures on Physiology
         - Action potential and synaptic transmission
         - Molecular mechanisms of muscle contraction
         - Renal physiology: kidney organization, nephrons, excretion and dialysis, homeostasis, regulation of pH, blood pressure and blood volume by hormones, renal failure, hemodialysis, peritoneal dialysis
         - Cardiovascular physiology, physiology of respiration : gas exchanges, gas transport, cardiac output, regulation of heart rate, blood pressure, hemostasis, main cardiovascular diseases and respiratoiry diseases
         - Regulation of blood glucose concentration
Lectures in neurosciences
          - Location and functions of the nervous system
          - Basic principles of neurosciences : cells, electrical properties of cell membranes, cell excitability, membrane channels, action potential, synapses, neurotransmitters, other kinds of transmission
          - Main physiological consequences of neurotransmission : post-synaptic potentials, synaptic dendritic integration, neuronal phenotypes, groups of cells, importance of connectivity
          - Neural coding : example of the muscle spindle, generalization, population coding
          - Central pattern generators : basic principles, example of the respiratory centers
          - Plasticity : short-term and long-term synaptic plasticity, structural plasticity (axonal and dendritic modifications)

Prerequisites: Molecular biology course and cell signaling course